Diffusion tensor imaging (DTI) has previously shown compromised white matter integrity in frontotemporal white matter fibers in patients with schizophrenia, as indicated by reduced fractional anisotropy (FA). In the present …more
In this paper, we describe the development of a new digital phantom designed for Monte Carlo simulations of breast cancer and particularly positron emission tomography (PET) imaging of the axillary …more
The effect of subject head movement on functional connectivity as measured by BOLD (blood oxygen level dependent) fMRI was investigated; movement mainly introduced increases in connectivity into the dataset. The …more
The aim of this study was to register and assess the accuracy of the superimposition method of a 3-dimensional (3D) soft tissue stereophotogrammetric image (C3D image) and a 3D image …more
The structure of the cation in the ylide hydrochloride [Me3NNHC(O)C6H4-Cl-p]Cl.H2O, or C10H14ClN2O+.Cl-.H2O, is compared with that of the free ylide. Protonation lengthens the N-C(O) bond but shortens the C=O and …more
Treatments currently licensed for Alzheimer’s dementia target cholinergic brain systems. In vivo nicotinic receptor binding may provide an early marker of illness and treatment suitability. In this pilot, we examined …more
CONTEXT: 5alpha-Reductase (5alphaR) types 1 and 2 catalyze the A-ring reduction of steroids, including androgens and glucocorticoids. 5alpha-R inhibitors lower dihydrotestosterone in benign prostatic hyperplasia; finasteride inhibits 5alphaR2, and dutasteride …more
Molecules of 13H-dibenzo[a,i]fluoren-13-one, C21H12O, straddle a crystallographic mirror plane and are essentially planar, with a dihedral angle of only 1.9 (1)degrees between the two naphthalene ring systems. Repulsive intramolecular C=O …more
Background and Purpose-Recently, a novel locus at 17q25 was associated with white matter hyperintensities (WMH) on MRI in stroke-free individuals. We aimed to replicate the association with WMH volume (WMHV) …more
Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [(18)F], was synthesised in radiofluorinated form. PET/CT Imaging with [(18)F] identified beta-amyloid over-expressing transgenic mice (betaA mice) compared …more
BACKGROUND: 18F-Sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) are promising novel biomarkers of disease activity in aortic stenosis. We compared 18F-NaF and 18F-FDG uptake with histological characterization of the aortic valve …more
[18F]-5-Fluoro-5-deoxyribose ([18F]-FDR) conjugates much more rapidly than [18F]-FDG under mild reaction conditions to peptides and offers new prospects for mild and rapid bioconjugation for fluorine-18 labelling in PET imaging.