previous research has suggested a possible link between the effects of scopolamine-induced muscarinic cholinergic receptor blockade on memory and its effect on auditory P3 amplitude and latency. A potential problem …more
It has recently been reported in a-chloralose anesthetized rats that the hemodynamic response to somatosensory stimulation almost doubled following transient hypercapnia (THC). In principle, this effect could be employed to …more
Background Development of emphysema and vascular stiffness in chronic obstructive pulmonary disease (COPD) may be due to a common mechanism of susceptibility to pulmonary and systemic elastin degradation. Objectives To …more
BACKGROUND AND PURPOSE: Systemic inflammation contributes to diverse acute and chronic brain pathologies, and extensive evidence implicates inflammation in stroke susceptibility and poor outcome. Here we investigate whether systemic inflammation …more
Objective: We describe the first clinical application of transient hyperoxia (“oxygen challenge”) during T2*-weighted magnetic resonance imaging (MRI), to detect differences in vascular deoxyhemoglobin between tissue compartments following stroke. Methods: …more
A significant and largely unsolved problem of computational fluid dynamics (CFD) simulation of flow in anatomically relevant geometries is that very few calculated pathlines pass through regions of complex flow. …more
OBJECTIVE: Pancreatic cancer is a leading cause of cancer-related death in the Western world. Current chemotherapy regimens have modest survival benefit. Thus, novel, effective therapies are required for treatment of …more
BACKGROUND AND PURPOSE: Intravenous recombinant tissue-type plasminogen activator (r-tPA), despite a risk of early symptomatic intracranial hemorrhage (sICH), is of net clinical benefit to acute stroke patients. We tested if …more
Visual object processing may follow a coarse-to-fine sequence imposed by fast processing of low spatial frequencies (LSF) and slow processing of high spatial frequencies (HSF). Objects can be categorized at …more
Objectives: Our purpose was to investigate whether differences exist in the values and temporal evolution of mean diffusivity () and fractional anisotropy (FA) of grey and white matter after human …more
In the title compound, hexa-mu-chloro-dichlorotetrakis(Ntrimethylammonio-p-toluenesulfonamidate -kappa(2)N,O)tetramer- cury(II), [Hg{Me3N(+)N(-)SO2C6H4CH3-p}Cl-2](4) or [Hg4Cl8(C10H16N2O2S)(4)], four nearly linear and parallel Cl-Hg-Cl units associate through pairwise Hg…Cl interactions of 3.1-3.2Angstrom. Each Hg atom is also coordinated …more