Introduction: [I-121]I-PK11195 is a high-affinity single photon emission computed tomography radiotracer for peripheral benzodiazepine receptors that has previously been used to measure activated microglia and to assess neuroinflammation in the …more

A patient with high-grade multi-focal glioma deteriorated rapidly despite high dose corticosteroid therapy (dexamethasone: 16 mg/day). MRI was used to measure diffusion tensor parameters and longitudinal relaxation time (T-1) values …more

Fast Field-Cycling MRI (FFC-MRI) is an emerging MRI technique that allows the main magnetic field to vary, allowing probing T1 at various magnetic field strengths. This technique offers promising possibilities …more

Background: Ischemic stroke is the leading cause of mortality worldwide and a major contributor to neurological disability and dementia. Terutroban is a specific TP receptor antagonist with antithrombotic, antivasoconstrictive, and …more

The reaction of N-phenyltriazolinedione with three simple alkyl-substituted alkenes in water/alcohol or water/acetone solution was found to give a mixture or the corresponding ene and water addition products. The new …more

The reaction of mono- or dichloro-dimolybdenum(III) complexes [Mo2Cp2(mu-SMe)(2)(mu-Cl)(mu-Y)] (Cp = eta(5)-C5H5; 1, Y = SMe; 2, Y = PPh2; 3, Y = Cl) with NaBH4 at room temperature gave in …more

Reactions of the trinuclear iron cluster [Fe3Cp2(CO)(3)(mu-CO)(mu(3)-CO)(mu(3)-CF3C2CF3)] (1) with the bis(phosphino) ligands dppm and dppe give different results: dppe yields mainly the hexanuclear compound (2) in which two tri-iron cluster …more

Problem Patients with transient ischaemic attack or stroke benefit from early diagnosis, specialist assessment, and treatment with thrombolysis, and from stroke unit care and secondary prevention. The challenge with such …more

Quantitative tractography may provide insights into regional heterogeneity of changes in white matter structure in normal ageing. Here we examine how brain atrophy and white matter lesions affect correlations between …more

Short-axis cine images are acquired during cardiac MRI in order to determine variables of cardiac left ventricular (LV) function such as ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), …more

Objectives Attenuation correction algorithms are required for accurate quantification of PET data and for mapping of radioactive tracers. Modern PET systems incorporate computed tomography (CT) systems to perform attenuation correction. …more

BACKGROUND AND PURPOSE In neuroimaging studies of dementia and mild cognitive impairment, hippocampal atrophy (HA) is commonly assessed by qualitative ratings of hippocampal appearance, or by measuring hippocampal volumes. These …more