We have synthesised novel oligo(ethylene glycol), CF3-terminated switching self-assembled monolayers, which allow the force experienced by a hydrophobic object to be controlled via the ionic strength of the environment.
Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?
Background-The pathogenesis of and relationship between small deep (lacunar) infarcts, cerebral white matter disease (leukoaraiosis or white matter hyperintensities), and progressive cognitive impairment or dementia are much debated. Summary of …more
Background: MR diffusion-weighted imaging (DWI) in ischemic stroke can be quantified by calculating the apparent diffusion coefficient (ADC) or measuring lesion volume. Objective: To clarify the association between DWI lesion …more
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) has typical clinical features that include stroke, migraine, mood disturbances and cognitive decline. However, misdiagnosis is common. We hypothesized that …more
Roudgari H, Farndon PA, Murray AD, Hardy C, Miedzybrodzka Z. Is PATCHED an important candidate gene for neural tube defects? Cranial and thoracic neural tube defects in a family with …more
It has been hypothesized that individual differences in cognitive ageing might in part be based on the relative preservation of speed of information processing. However, the biological foundations of processing …more
The N400 is one of the most widely studied ERP components and has come to be viewed as an index of the semantic processing that relates distinct stimuli. In this …more
Objective: End-stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end-stage coagulation in healthy volunteers account for …more
The UltiPaq(TM) very soft, stretch-resistant coil is a useful new addition to the coil range available to neurointerventionists. Its highly compliant character makes it very suitable for small, ruptured aneurysms, …more
The C-F bond-forming step in the fluorinase, the only native fluorination enzyme characterized to date, has been studied. The enzyme catalyzes the reaction between S-adenosyl-L-methionine (SAM) and fluoride ions to …more
Background and Purpose-Insular cortex ischemia is proposed to mediate a sympathetic stimulus that leads to acute hyperglycemia after stroke. Methods-We retrospectively analyzed insular perfusion on perfusion CT (median 180 minutes …more