Background: The objective of this study was to determine whether: (a) markers of acute inflammation (white cell count, glucose, interleukin-6, C-reactive protein, and fibrinogen) are associated with poor outcome after …more
Aim: We sought to determine whether there were differences between men and women with acute stroke in their baseline characteristics and outcome in a large cohort of patients randomized in …more
Introduction: It is generally assumed that intracranial volume (ICV) remains constant after peaking in early adulthood. Thus ICV is used as a ‘proxy’ for original brain size when trying to …more
Targeted radiotherapy using (131)I-metaiodobenzylguanidine ((131)I-MIBG) has produced remissions in some neuroblastoma patients. We previously reported that combining (131)I-MIBG with the topoisomerase I inhibitor topotecan induced long-term DNA damage and supraadditive …more
Objective To estimate the impact on long term survival of functional status at six months after ischaemic stroke. Design Prospective cohort study. Settings Three cohorts: Oxfordshire community stroke project, Lothian …more
Background: Obtaining informed consent for a patient’s participation in a randomized trial of treatment for use in a medical emergency may be achieved in a variety of ways. We sought …more
Goal-driven control over saccade target selection requires the inhibition of task-irrelevant, stimulus-driven saccades. A widely held assumption is that frontal structures are of critical importance for this function. Here we …more
Background: Intravenous alteplase is licensed for treatment of ischaemic stroke within 3h of onset. Up to one-third of patients in the UK present to hospital within this time window but …more
The field of tractography is rapidly developing, and many automatic or semiautomatic algorithms have now been devised to segment and visualize neural white matter fasciculi in vivo. However, these algorithms …more
Tritium-labelled fluoroazomycin arabinoside, [H-3]-FAZA, is a useful probe for the investigation of hypoxia, furthermore it is safer and easier to handle than the PET tracer [F-18]-FAZA when used in cell …more
Background and Purpose-If the diagnostic and prognostic significance of brain microbleeds (BMBs) are to be investigated and used for these purposes in clinical practice, observer variation in BMB assessment must …more