We aimed to characterize dementia with Lewy bodies (DLB) by the quantitative MRI parameters of longitudinal relaxation time (qT1) and transverse relaxation time (qT2). These parameters reflect potential pathological changes …more
Aldol reaction utilising Evans N-(alpha-fluoropropyl)-2-oxazolidinones with TiCl4 have been explored. Reactions of N-(alpha-fluoropropyl)-2-oxazolidinones with aliphatic aldehydes generated (x-fluoro-p-hydroxy-aldol products with high diastereoselectivities. When (alpha R)- and (alpha S)-N-(alpha-fluoropropyl)-2-(4S)-oxazolidinones were explored …more
This paper discusses concisely the main issues and challenges posed by the validation of retinal image analysis algorithms. It is designed to set the discussion for the IEEE EBMC 2013 …more
The aim of this investigation Was to assess the feasibility of building a virtual human face digitally by superimposing a photo-realistic three-dimensional (3D) soft-tissue surface on bone in the correct …more
Enlarged perivascular spaces (EPVS), visible in brain MRI, are an important marker of small vessel disease and neuroinflammation. We systematically evaluated the literature up to June 2012 on possible methods …more
The herpes simplex virus (HSV) ICP34.5 null mutant 1716 replicates selectively in actively dividing cells and has been proposed as a potential treatment for cancer, particularly brain tumours. We present …more
Understanding how ageing affects brain structure is an important challenge for medical science. By allowing segmentation of fasciculi-of-interest front diffusion magnetic resonance imaging (dMRI) data, tractography provides a promising tool …more
A series of chemical and electrochemical transformations of systems in which a {Mo2CP2(mu-SMe)(3)} core is bridged by a mu-C2HnR ligand (n = 0-4) are described in this paper. The reaction …more
The bis(nitrile) compound [MO2CP2(mu-SMe)(3)(MeCN)(2)](BF4) (1) (CP = C5H5) reacted with substituted hydrazines RNHNH2 (R = Me, Ph) in acetonitrile at room temperature to give the stable diazene species [Mo2CP2(9-SMe)3 (mu-eta(2)-HN= …more
Objectives. To look for evidence of early ischaemic neurochemical changes in patients suffering severe traumatic brain injury (TBI) and severe subarachnoid haemorrhage (SAH). Proton metabolite concentrations were measured in normal …more
Background Treatment strategies for acute basilar artery occlusion (BAO) are based on case series and data that have been extrapolated from stroke intervention trials in other cerebrovascular territories, and information …more
Background and Purpose-Controversy regarding the risks and benefits of thrombolysis has not been helped by the perception that some trials were “positive” and others “negative” on their primary outcome measure …more