Fluorine is the most electronegative element in the periodic table. When bound to carbon it forms the strongest bonds in organic chemistry and this makes fluorine substitution attractive for the …more
We explored properties of whole brain networks based on multivariate spectral analysis of human functional magnetic resonance imaging (fMRI) time-series measured in 90 cortical and subcortical subregions in each of …more
Reaction of the bis-isonitrile complex [Mo-2-Cp-2(mu-SMe)(3)(t-BuNC)(2)](BF4) (1) with n-BuLi (in hexane) produced the dealkylated derivative [Mo2Cp2(mu-SMe)(3)(t-BuNC)(CN)] (2) in quantitative yield. However, upon treatment with either NaOH (suspension) or (Me4N)OH (in …more
A novel example of C-S bond cleavage in a dimolybdenum derivative leads to the formation of the quadruply bridged compound [Mo(IV)(2)Cp-2(mu -O)(mu -S)(mu -SMe)(2)]. This mu -oxo species is formed …more
Between 3.6 and 6% of the population harbour an unruptured intracranial aneurysm. Risk of rupture is related to aneurysm site and size and whether or not the patient has already …more
Here we report the synthesis of 4-tricyclanol, 6, via an unusual route and its characterisation, by single crystal X-ray diffraction studies. The crystal structure of 6 shows extended hydrophobic channels …more
BACKGROUND:Intravenous recombinant tissue plasminogen activator (rtPA) is approved in Europe for use in patients with acute ischaemic stroke who meet strictly defined criteria. IST-3 sought to improve the external validity …more
The objective of this work was to propose and demonstrate a novel technique for the assessment of tumour pharmacokinetic parameters together with a regionally estimated vascular input function. A breast …more
There is growing interest in investigating the role of subtle changes in blood-brain barrier (BBB) function in common neurological disorders and the possible use of imaging techniques to assess these …more
The ability of people with dementia to participate in social interactions is progressively undermined by the illness. This is due in part to memory and speech production difficulties but also …more
Angular momentum transport within young massive protoplanetary discs may be dominated by self-gravity at radii where the disc is too weakly ionized to allow the development of the magneto-rotational instability. …more