A stereoselective 10-step synthesis of iodophenoxy analogues of (2R,3S)-reboxetine has been developed with the aim of generating a new SPECT imaging agent for the noradrenaline transporter (NAT). In vitro testing …more

The paper draws on a number of Grid projects, particularly on the experience of NeuroGrid a UK project in the Neurosciences tasked with developing a Grid-based collaborative research environment to …more

RATIONALE: Thrombolysis with intravenous alteplase is both effective and safe when administered to particular types of patient within 4.5 hours of having an ischemic stroke. However, the extent to which …more

BACKGROUND: Acute ischemic stroke is common and disabling, but there remains a paucity of acute treatment options and available treatment (thrombolysis) is underutilized. Advanced brain imaging, designed to identify viable …more

Proliferative diabetic retinopathy is a rare condition likely to lead to severe visual impairment. It is characterized by the development of abnormal new retinal vessels. We describe a method for …more

It is known that in the early stages of osteoarthritis, the concentration of glycan proteins decreases in articular cartilage. This phenomenon is under active research to develop a means to …more

Purpose: To compare hyperpolarized helium-3 margnetic resonance imaging (He-3-MRI) acquired from non-small cell lung cancer (NSCLC) patients before and after external beam radiotherapy (EBRT). Methods and materials: In a ethics …more

Background: The identification of viable myocardium in patients with impaired left ventricular contraction secondary to coronary heart disease is important clinically as such myocardium is likely to benefit from revascularisation. …more

The increasing availability of rodent models of human cardiovascular disease has led to a need to translate noninvasive imaging techniques such as magnetic resonance imaging (MRI) from the clinic to …more

Interpretation of brain images from older patients requires knowledge of changes that occur with healthy ageing. We constructed and tested a reference template for older subjects. We used MR images …more

We are currently developing a multilayer avalanche photodiode (APD)-based detector for use in positron emission tomography (PET), which utilizes thin continuous crystals. In this paper, we developed a Monte Carlo-based …more

We are currently developing a multi-layer APD based detector for use in PET that utilizes thin continuous crystals. In this work we developed a Monte-Carlo based simulation to aid in …more

Tubulysins are highly toxic tubulin-targeting agents with a narrow therapeutic window that are interesting for application in antibody-drug conjugates (ADC). For full control over drug-antibody ratio (DAR) and the effect …more

Introduction: I-123-NKJ64, a reboxetine analogue, is currently under development as a potential novel single photon emission computed tomography radiotracer for imaging the noradrenaline transporter in brain. This study describes the …more