BACKGROUND AND PURPOSE: Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change. We investigated their concentration variation over …more

PURPOSE: To test the hypothesis-given the increasing emphasis on quantitative computed tomographic (CT) phenotypes of chronic obstructive pulmonary disease (COPD)-that a relationship exists between COPD exacerbation frequency and quantitative CT …more

There is evidence for the involvement of the cingulate gyrus in schizophrenia. We present details of a Statistical Parametric Mapping (SPM) analysis of SPECT data from the largest study (N …more

Cognitive prostheses interact with human cognitive abilities to extend an individual’s capacity. They have application both with healthy functioning individuals and those who have suffered brain injury. In Alzheimer’s disease …more

BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) and perivascular spaces (PVS) are features of small vessel disease, found jointly on MRI of older people. Inflammation is a prominent pathological feature …more

1-Phenyl-2,3,4,5-tetramethylphosphole reacts with [Mo(CO)(6)] to give the mono- and bis(phosphole) complexes [Mo(CO)(5)L] and cis- and trans-[Mo(CO)(4)L-2], where L=C4Me5PPh (tmpPh). The new complexes have been characterised by spectroscopic methods, supplemented by …more

Reverse correlation methods have been widely used in neuroscience for many years and have recently been applied to study the sensitivity of human brain signals ( EEG, MEG) to complex …more

BACKGROUND: Chronic bronchitis (CB) has been related to poor outcomes in Chronic Obstructive Pulmonary Disease (COPD). From a clinical standpoint, we have shown that subjects with CB in a group …more

OBJECTIVES: Transient ischaemic attack (TIA) is a medical emergency requiring rapid access to effective, organised, stroke prevention. There are about 90 000 TIAs per year in the UK. We assessed …more

BACKGROUND: Severe hypoxemia is a major complication of chronic obstructive pulmonary disease (COPD). Long-term oxygen therapy is beneficial in hypoxemic COPD patients. However, the clinical and radiographic predictors of hypoxemia …more

Background and Purpose-Associations among microbleeds, white matter lesions (WMLs), and small deep infarcts on imaging have been reported. Because many of these imaging infarcts were as asymptomatic, the relationship of …more

New developments in fast magnetic resonance imaging (MRI) have enabled imaging of cerebral haemodynamics. This article describes the theory behind perfusion imaging and provides an overview of the most commonly …more

Normal listeners effortlessly determine a person’s gender by voice, but the cerebral mechanisms underlying this ability remain unclear. Here, we demonstrate 2 stages of cerebral processing during voice gender categorization. …more