Courtesy of Dr Sally Pimlott, this sagittal SPECT image of a psoriatic arthritis patient shows [123I]-beta-CIT uptake at 4 hours in the brainstem (arrows) – before (top row) and after (bottom row) treatment with Etanercept.

The image is taken from a recent study published in Brain, Behavior, and Immunity:

Krishnadas R, Nicol A, Sassarini J, Puri N, Burden AD, Leman J, Combet E, Pimlott S, Hadley D, McInnes IB, Cavanagh J. Circulating Tumour Necrosis Factor is highly correlated with brainstem serotonin transporter availability in humans. Brain, Behavior, and Immunity. Available online 6 August 2015.