Background: Early signs of ischaemic stroke on computerised tomography (CT) scanning are subtle but CT is the most widely available diagnostic test for stroke. Scoring methods that code for the …more
A strategy for last-step F-18 fluorination of bioconjugated peptides is reported that exploits an “Achilles heel” in the substrate specificity of the fluorinase enzyme. An acetylene functionality at the C-2 …more
PURPOSE: To investigate MRI biomarkers of muscle atrophy during cast immobilization of the lower leg. MATERIALS AND METHODS: Eighteen patients (8 male, 10 female), who had one lower leg immobilized …more
Radiation exposure in cardiac imaging is a major healthcare concern and low-dose cardiac imaging has important implications for patients. We describe the application of a low-dose comprehensive cardiac computed tomography …more
The crystal structure of trimethylammonio n-hexadecylsulfonamidate contains antiparallel monolayers stabilized by strong C-(HO)-O-… bonds ((CO)-O-… 3.22 Angstrom). There are also significant C-(HX)-X-… (X = N, O) bonds linking adjacent layers. …more
Scintillation detectors developed for PET traditionally uses relatively thick crystals (to ensure good efficiency), which are coupled to photomultiplier tubes. The crystals typically measure between 10 and 30mm thick Detectors …more
Modern advances in magnetic resonance (MR) and computed tomography (CT) perfusion imaging techniques have developed methods for myocardial perfusion assessment. However, individual imaging techniques present limitations that are possible to …more
NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia, but no functional mutation causally related to the disorder has yet been identified. Here we investigate the effects of a …more
Mammalian gonadotropin-releasing hormone (GnRH I: pGlu-His-TrpSer-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) stimulates pituitary gonadotropin secretion, which in turn stimulates the gonads. Whereas a hypothalamic form of GnRH of variable structure (designated type I) had been …more
The parietal lobe has long been viewed as a collection of architectonic and functional subdivisions. Though much parietal research has focused on mechanisms of visuospatial attention and control-related processes, more …more
Aims: Delays between surgery and the delivery of radiotherapy may allow brain tumours to grow beyond the planned radiotherapy fields and therefore reduce the effectiveness of radiotherapy. This pilot study …more
MR diffusion/perfusion mismatch may help identify patients for acute stroke treatment, but mixed results from clinical trials suggest that further evaluation of the mismatch concept is required. To work effectively, …more
Since the invention of diffusion magnetic resonance imaging (dMRI), currently the only established method for studying white matter connectivity in a clinical environment, there has been a great deal of …more