This article outlines the clinical presentation, neuroradiological approach, and the application of helpful ancillary investigations in the diagnosis of a range of cranial nerve syndromes. These syndromes are characterised by …more

N-(2 Naphthyl)-N’-(3-[I-125]-iodophenyl)-N’-methylguanidine ([I-125]-CNS 1261) was syn thesized as a potential radioligand to image N-methyl-D-aspartate (NMDA) receptor activation. [I-125]-CNS 1261 was prepared by radioiodination of N-(1 naphthyl)-N’-(3-tributylstannyphenyl)-N’-methylguanidine using (NaI)-I-125 and peracetic …more

A focused library of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones containing sites for C-11-, F-18- and I-123-labelling have been prepared and evaluated against membrane expressing human recombinant metabotropic glutamate 2 receptor (mGluR2). The compounds …more

Skeletal muscle viscoelastic properties reflect muscle microstructure and neuromuscular activation. Elastographic methods, including magnetic resonance elastography, have been used to characterize muscle viscoelastic properties in terms of region of interest …more

Stroke is a common and disabling condition that represents a potentially attractive target for regenerative therapy. Stem cells from a wide range of origins have been investigated in studies using …more

Stroke, for some years now the neglected major indication in the pharmaceutical development cupboard, has recently become one of the hot areas for stem cell therapy development. This is driven …more

Background: Asymmetric introduction of fluorine alpha- to a carbonyl has become popular recently, largely because the direct fluorination of enolates by asymmetric electrophilic fluorinating reagents has improved, and as a …more

Reactions involving the conversion of a benzylic alcohol into a benzylic fluoride using RSF3 reagents are notoriously difficult to achieve with high stereochemical inversion (S(N)2 reaction) due 70 competing dissociative …more

A core social-psychological question is how cultural stereotypes shape our encounters with other people. While there is considerable evidence to suggest that unexpected targets-such as female airline pilots and male …more

The recently published second Surgical Trial in Intracerebral Haemorrhage (STICH-2) tested whether surgical evacuation of superficial spontaneous intracerebral haemorrhage was effective at reducing death and disability at 6 months after …more

Stroke is a major public-health burden worldwide. Prevention programmes are essential to reduce the incidence of stroke and to prevent the all but inevitable stroke epidemic, which will hit less …more

Introduction Small primary intracerebral haemorrhages (PICHs) cause mild stroke symptoms and resolve rapidly on CT. Delays in imaging in stroke incidence studies may therefore have inadvertently led to an underestimate …more

Background and Purpose-Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality, and stroke outcome across geographical …more

Accurate identification of ischemic penumbra will improve stroke patient selection for reperfusion therapies and clinical trials. Current magnetic resonance imaging (MRI) techniques have limitations and lack validation. Oxygen challenge T(2)(*) …more