Over-diagnosis of Parkinson’s disease (PD) is suggested by specialist review of community diagnosis, and in postmortem studies. In specialist centers 4 to 15% of patients entered into clinical trials as …more

Neuroimaging is often pilloried for providing little more than pretty pictures that simply show where activity occurs in the brain. Strong critics (notably Uttal) have even argued that neuroimaging is …more

We report a case of an interventricular ependymoma which was surgically removed but also required bilateral transection of the fornices resulting in memory impairment which gradually improved. Functional MR images …more

Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found …more

We evaluated arterial oxygen saturation (SaO(2)) and heart rate in acute stroke patients to determine whether routine positioning affected these physiological parameters. Measurements were recorded at the bedside noninvasively in …more

BACKGROUND: NXY-059 is a free-radical-trapping agent that is neuroprotective in animal models of stroke. We tested whether it would reduce disability in humans after acute ischemic stroke. METHODS: We conducted …more

We present measurements of B meson decays to the final states omega K*, omega rho, and omega f(0), where K* indicates a spin 0, 1, or 2 strange meson. The …more

Purpose-We aimed to determine intraobserver and interobserver agreement in the characterization of brain arteriovenous malformation (AVM) angioarchitecture on intra-arterial digital subtraction angiograms. Methods-Five experienced interventional neuroradiologists independently reviewed 40 anonymized …more

INTRODUCTION: CT angiography (CTA) is often used for assessing patients with acute ischaemic stroke. Only limited observer reliability data exist. We tested inter- and intra-observer reliability for the assessment of …more

The cruciform model posits that if a Visual Evoked Potential component originates in cortical area V1, then stimuli placed in the upper versus lower visual field will generate responses with …more

The strong sensitivity of Carr-Purcell-Meiboom-Gill (CPMG) fast spin-echo (FSE) sequences, such as rapid acquisition with relaxation enhancement (RARE), to the phase of the prepared transverse magnetization means that artifact-free single-shot …more

In abdominal aortic aneurysm disease, the aortic wall is exposed to intense biological activity involving inflammation and matrix metalloproteinase-mediated degradation of the extracellular matrix. These processes are orchestrated by monocytes …more

Eddy current induced geometric distortions can only be accurately corrected in brain diffusion-weighted echo-planar (DW-EP) images for b-values less than approximately 300 s mm(-2) using the iterative cross-correlation (ICC) algorithm. …more

The accurate determination of absolute measures of diffusion anisotropy in vivo using single-shot, echo-planar imaging techniques requires the acquisition of a set of high signal-to-noise ratio, diffusion-weighted images that are …more