Recently a fluorination enzyme was identified and isolated from Streptomyces cattleya, as the first committed step on the metabolic pathway to the fluorinated metabolites, fluoroacetate and 4-fluoro-threonine. This enzyme, 5′-fluoro-5′-deoxy …more
The term cerebral small vessel disease (SVD) describes a range of neuroimaging, pathological, and associated clinical features. Clinical features range from none, to discrete focal neurological symptoms (eg, stroke), to …more
During the biosynthesis of certain tropane alkaloids, littorine (1) is rearranged to hyoscyamine (3). Recent evidence indicates that this isomerisation is a two-step process in which the first step is …more
Management of stroke has been revolutionised over the past decade, and therapeutic where the window of opportunity for intervention is very short and the treatment carries nihilism is no longer …more
Sixteen clinically depressed patients and sixteen healthy controls were presented with a set of emotional facial expressions and were asked to identify the emotion portrayed by each face. They were …more
This paper describes a cross-sectional case control study to measure the prevalence of psychological morbidity in first year medical students and compare it to the prevalence in in a randomly …more
The title complex, [Ni(C7H3NO4)(C6H5N3)(3)], has been prepared hydrothermally. Three neutral monodentate benzotriazole ligands occupy meridional sites about the octahedrally coordinated nickel(II) cation. The remaining sites are occupied by the N …more
High-resolution MRI scans, in conjunction with CAD software, were used to determine the three-dimensional moment arms and force vector direction cosines For 11 structures passing the interphalangeal and metacarpophalangeal joints …more
Attempts at methylating cis-[MO2CP2(mu-SMe)(3)L-2](BF4) [CP = eta(5)-C5H5; L = CO (1a) CNxyl (1b), CNBu'(1c), NCMe (1d)] with methyl triflate gave the corresponding thioether-bridged cations [Mo2CP2(mu-SMC)(2)(v-SMe2)L-2](2+) (4(2+)), except in the case …more
Background-Patent foramen ovale (PFO) is prevalent in patients with migraine with aura. Observational studies show that PFO closure resulted in migraine cessation or improvement in approximate to 80% of such …more