Dynamic contrast enhanced MRI (DCE-MRI) and pharmacokinetic models have been used to measure tumour permeability (K-trans) and leakage volume (v(e)) in numerous studies. The construction of pharmacokinetic models describing such …more

Objectives. We examined the effects of rumination and distraction on over-general autobiographical memory (AM) retrieval during social problem solving (SIPS), as well as SPS performance in terms of means and …more

While it is well documented that autobiographical memory (ABM) recall is affected in Posttraumatic Stress Disorders (PTSD), less is known about the cognitive mechanisms that underlie this pattern. This paper …more

Aim: to describe our experience with a series of 18 patients with pericallosal artery aneurysms, in whom endovascular coil insertion was attempted. Method: the CT and angiographic appearances, coiling techniques …more

Systematic screening for diabetic retinopathy using retinal photography has been shown to reduce the incidence of blindness among people with diabetes. The implementation of diabetic retinopathy screening programmes faces several …more

Felsenstein distinguished two ways by which selection can directly strengthen isolation. First, a modifier that strengthens prezygotic isolation can be favored everywhere. This fits with the traditional view of reinforcement …more

Relatives of people with aneurysmal subarachnoid haemorrhage (SAH) may be at increased risk of SAH, but precise data on the level of risk and which relatives are most likely to …more

This paper describes an incident in which an apparently normal hospital pillow became a ferromagnetic missile when brought into the proximity of a 1.5 T MR system owing to a …more

The use of the key enzyme involved in carbon-fluorine bond formation in Streptomyces cattleya catalysing the formation of 5′-fluoro-5′-deoxyadenosine (5′-FDA) from fluoride ion and S-adenosyl-L-methionine (SAM) was explored for its …more

dPestalotiopsin A is a structurally unique, caryophyllene-type sesquiterpene which has shown immunosuppressive activity and cytotoxicity in preliminary assays. A stereocontrolled approach to the functionalised 2-oxabicyclo[3.2.0]-heptane core of pestalotiopsin A is …more

The fluorinase from Streptomyces cattleya and chlorinase from Salinispora tropica have a commonality in that they mediate nucleophilic reactions of their respective halide ions to the C-5′ carbon of S-adenosyl-L-methionine …more

(+/-)-Erythro-and(+/-)-threo-9,10-difluorostearic acids which differ only by a stereogenic interconversion of a single C-F bond, have significantly different conformational stabilities.

Twenty healthy young adults underwent functional magnetic resonance imaging (fMRI) of the brain while performing a visual inspection time task. Inspection time is a forced-choice, two-alternative visual backward-masking task in …more