The human gonadotropin-releasing hormone ( GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5), Leu(7), Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5), Trp(7), Tyr(8)]GnRH). …more

Background and Purpose-It is generally considered that tissue that appears abnormal on T2 MRI is already infarcted and that any penumbra lies outside the T2-visible lesion. We investigated the distribution …more

Numerous trials of haemostatic and neuroprotective agents for intracerebral haemorrhage (ICH) have failed. We characterized the risk of complications after ICH in a trial-eligible patient population, to inform safety in …more

Background: Two important consequences of the normal ageing process are sarcopenia (the age-related loss of muscle mass and function) and age-related cognitive decline. Existing data support positive relationships between muscle …more

For the past few decades membrane zinc metallopeptidases have been identified as important therapeutic targets in the control of pain. In particular, neutral endopeptidase (NEP) has been shown to play …more

OBJECTIVE: The aim of this study was to investigate the neurophysiological effects of fatigue among patients with granulomatosis with polyangiitis (GPA). METHODS: A case-control functional MRI (fMRI) study was conducted. …more

Imitation is crucial for social learning, and so it is important to identify what determines between-subject variability in imitation fidelity. This might help explain what makes some people, like those …more

This study investigated event-related potential (ERP) effects when judgments about temporal context (recency judgments) required the retrieval of different amount of information. Subjects studied two consecutively presented word lists and …more

Recent evidence suggests that the molecular defects associated with the development of diabetes also contribute to an increased risk of all types of dementia, including Alzheimer’s disease, vascular dementia and …more

Rhizobial soil bacteria can form a symbiosis with legumes in which the bacteria fix atmospheric nitrogen into ammonia that can be utilized by the host. The plant, in turn, supplies …more

The development of positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging continues to grow due to the ability of these techniques to allow the non-invasive in …more

We have compared 2-deoxy-2-[F-18]-fluoro-D-glucose positron emission tomography (FDG-PET) images of large or locally advanced breast cancers (LABC) acquired during Anthracycline-based chemotherapy. The purpose was to determine whether there is an …more

BACKGROUND AND PURPOSE:White matter hyperintensities are characteristic of old age and identifiable on FLAIR and T2-weighted MR imaging. They are typically separated into periventricular or deep categories. It is unclear …more